Design And Characterization of Chitosan Nanoparticles Containing Telmisartan for Controlled Drug Delivery System (Research Article)

Author(s): S. Selvaraj*, A. Muthumanikandan and P. Perumal

Abstract: This study aimed to formulate and evaluate Telmisartan-loaded chitosan nanoparticles using the ionic gelation technique to enhance drug solubility, bioavailability and achieve sustained drug release. Telmisartan-loaded chitosan nanoparticles were prepared by ionic gelation using chitosan as the polymer and sodium tripolyphosphate (STPP) as the cross-linking agent. Formulations were optimized by varying polymer concentration and sonication time. The prepared nanoparticles were characterized for particle size, zeta potential, morphology, drug entrapment efficiency and in vitro drug release. Drug–polymer compatibility was assessed using Fourier Transform Infrared (FTIR) spectroscopy. The optimized formulation exhibited a mean particle size of approximately 180 nm, a positive zeta potential indicating good colloidal stability and an entrapment efficiency exceeding 85%. The in-vitro drug release profile demonstrated a sustained, controlled release following zero-order kinetics with a non-Fickian diffusion mechanism. In vitro release studies demonstrated sustained drug release over 24 hours with improved dissolution compared to the marketed formulation.

PAGES: 98-107  |  34 VIEWS  4 DOWNLOADS