Evaluation of in Vitro Antiparasitic Activity Against Haemonchus Contortus (Research Article)

Author(s): Y.M. Koffi, *, K. Bene, A. Toure, B.F.H. Tra, M.W. Kone2

Abstract: Intestinal nematodes continue to pose a major constraint in small ruminant production. Across the globe, each country is actively seeking innovative, cost-effective, and environmentally sustainable strategies to improve control of these parasites. Among the promising alternatives, livestock-consumed plants are increasingly being explored for their potential in managing gastrointestinal nematodes in domestic ruminants. This study aimed to evaluate the anthelmintic potential of three forage plants from the local flora for the control of digestive tract nematodes in small ruminants. To achieve this, adult worms of the nematode Haemonchus contortus Rudolphi (Trichostrongylidae) were incubated in Petri dishes and exposed for a specific duration to hydromethanolic leaf extracts of Albizia adianthifolia, Ficus lutea, and Morus mesozygia. The in vitro anthelmintic assays revealed that F. lutea and A. adianthifolia exhibited adulticidal activity against H. contortus worms. Notably, A. adianthifolia demonstrated the highest efficacy, causing 100% mortality of adult worms after 24 hours of exposure. These findings underscore the ecological value of forage plants in the sustainable control of gastrointestinal nematodes affecting sheep and goats.

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