Formulation And Evaluation of Chlorhexidine, Aloe Vera Gel Sodium Alginate Beads Incorporated Gel for Topical Application (Research Article)

Author(s): Sirisha. Y*

Abstract: The aim of this project was to develop a novel gel formulation by incorporating chlorhexidine, aloe vera, and sodium alginate beads, and to evaluate its properties for potential pharmaceutical and therapeutic applications. The gel was formulated using aloe vera gel as the base, incorporating chlorhexidine as the antimicrobial agent, and sodium alginate beads for sustained release. The formulation process involved optimizing the concentrations of each component to achieve desired viscosity, drug release profile, and stability. Various physicochemical properties of the gel were evaluated, including pH, viscosity, drug content, stability, spreadability and rheological behavior. The developed gel exhibited desirable properties such as suitable pH, viscosity for topical application, controlled release of chlorhexidine, and significant antimicrobial activity against tested microorganisms. Stability studies indicated good shelf-life under recommended storage conditions. In conclusion, the formulated chlorhexidine-aloe vera-sodium alginate beads incorporated gel holds promise as a potential topical antimicrobial agent with sustained release properties, suitable for various pharmaceutical and therapeutic applications. Further studies including in vivo evaluations are warranted to validate its clinical efficacy and safety.

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