The Investigation of Anti Hypertension and Cardioprotective Properties of Cassia Fistula Linn Leaf Extract in Experimental Animals (Research Article)

Author(s): Omkarswamy Maradimath*, Shaista Omer, Ittagi Shanmukha, Sachin Wali and Prashanth K U. Darshan Angadi

Abstract: Objective: This study was designed to determine the Anti-hypertension and Cardioprotective properties of leaves of Cassia fistula. Hypertension drives the global burden of cardiovascular disease and its prevalence is estimated to increase by 30% by the year 2025. Nonadherence to chronic medication regimens is common; approximately 43% to 65.5% of patients who fail to adhere to prescribed regimens are hypertensive patients. Nonadherence to medications is a potential contributing factor to the occurrence of concomitant diseases. Results: Significant decrease in the elevated level of serum glucose, TG, cholesterol, pulse rate and also there is a decrease in the organ weight such as heart in the anti- hypertension models. The treatment with test extract has reversed all the biochemical parameters in cardiotoxicity to the near normal levels in a dose dependant manner. Histopathological observations confirmed the same. Conclusion: From the results it may be concluded that the 70% EELCF possess anti- hypertension and cardioprotective activities. The anti-hypertension and organ protective properties of the plant may be attributed to the alkaloids, terpenoids, steroid, volatile oil, sterols, saponins and polyphenolic compounds like flavonoids and tannins that are present in the plant.

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