Formulation, Characterization, and in vitro Evaluation of Chlorzoxazone Floating Microspheres (Research Article)

Author(s): Selva Meena.M, Umamaheswari.D*, Abdul Hasan Shathali.A, Senthil Prabhu.R

Abstract: Chlorzoxazone is a centrally acting agent for painful musculoskeletal conditions. Chlorzoxazone microspheres were facilitated by preparing floating dosage form which could increase its absorption by increasing the gastric residence time and to achieve sustainable drug release. Chlorzoxazone floating microspheres were prepared by emulsion solvent evaporation method in 10 different formulations (F1-F10) using Ethyl cellulose and HPMCK15 as polymers, tween 80 as surfactant, Ethanol and Dichloro methane were used as solvents. The influence of formulation factors (drug-polymer, stirring speed, concentration of surfactant and solvent ratio) on particle size, encapsulation efficiency and in-vitro release characteristics of the microspheres were investigated. The prepared formulations were evaluated with pre-compression parameters like bulk density, compressibility index, hausner ratio, angle of repose and post- compression parameters like drug content, percentage yield, drug entrapment efficiency, floating lag time, total floating time, and in-vitro drug release. All the formulation possesses good flow property, start to float within 40 sec. with a total floating time for not less than 12hrs. In-vitro drug release and floating behavior were studied in stimulated gastric fluid at pH 1.2 was found to 54.27% and 85.06% of the optimized formulation F9. The yield and percentage entrapment efficiency of microspheres was obtained up to 81.48% and 84.47%. Kinetic studies of the optimized formulation (F9) showed that the drug release follows Higuchi model and Peppa’s plot stated non-fickian diffusion controlled.

PAGES: 118-127  |  31 VIEWS  42 DOWNLOADS