Formulation and Evaluation of Mouth Dissolving Tablets of Levocetirizine Dihydrochloride (Research Article)

Author(s): Vijay Yadav*, Sharad Pudasaini, Pooja Shree Koirala, Lalita Laghu, Sarita Poudel, Sangita Kumari Sah, Rabindra Kumar Rokaya, Kedar Prasad Shah, Nabin Thapa Magar, Lalit Mohan Pant

Abstract: Background: Synthetic super disintegrants are used in the tablet formulation to improve the rate and extents of tablet disintegration thereby increasing the rate of drug dissolution. Aim: The purpose of the present study was to formulate levocetirizine orodispersible tablets using starch glycate and croscarmellose as super disintegrants to improve the onset of action, therapeutic efficacy, patient compliance and convenience. Methodology: Altogether eight formulations of Levocetirizine tablets were prepared by direct compression method. The powder blend was initially studied for pre-compression parameters and compressed tablets were evaluated for thickness, hardness, weight variation test, wetting time, disintegrating time, content uniformity, friability test etc. Result: Hardness, friability, weight variation, thickness and diameter of each formulation were evaluated and were found to be under the limit. Rapid disintegration within minutes was observed in all the formulations. With the addition of super disintegrants, the disintegration time increased significantly. (n=3) Based on the disintegration time, formulation F2 and F3 were found to be promising and showed a rapid disintegration time of 19±3.5sec and 25±3.0sec respectively. Conclusion: Mouth dissolving tablets of Levocetirizine for quick relief from allergy can be prepared by using commercially used superdisintegrants such as starch glycate and croscarmellose sodium by direct compression technique.

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