Myasthenia Gravis - A Review on Pharmacotherapy (Review Article)

Author(s): Naveen Poojar CM

Abstract: Myasthenia gravis (MG) is an autoimmune disorder characterized by fluctuating muscular weakness, which is relieved by cessation of activity and aggravated by intense physical activity. In MG, Ach is released normally but its effect on the postsynaptic membrane reduced. The autoantibody against AChRs will result in the destruction of postsynaptic membrane and reduction in the number of available Ach receptors on the muscle end plate membrane. The aim of treatment in a myasthenia gravis patient is maximum and sustained reduction in symptoms, attainment of full functional capacity and minimizing the side effects of drug therapy. The treatment modalities are acetylcholinesterase inhibitors, corticosteroids, immunosuppressants, plasmapheresis, immunogobulins and thymectomy.

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