Design, Synthesis of Novel Ethylene Bridged N-Acyl Homoserine Lactones as Inhibitors of Quorum Sensing Signaling in Pathogenic Bacteria to Prevent Biofilm Formation (Research Article)

Author(s): Ratnam Alivelu, Baishali Mohanta*, Yadala Jahnavi, Boda Uday Kiran, Sruthi K and Kondapalli Naresh

Abstract: Gram-negative bacteria such as Pseudomonas aeruginosa use N-acylated L-homoserine lactones (AHLs) as autoinducers (AIs) for quorum sensing (QS) signaling, a chief regulatory protein responsible for cell-to-cell communication system in bacteria. QS are responsible for social adaptation, virulence factor production, biofilm production and antibiotic resistance in bacteria. Inhibition of this communication signaling system could lead to an effective treatment of pathogenic bacterial infections. Hence, quorum sensing signaling proteins attracted greater attention and considered as novel targets to develop drugs acting against drug resistant bacterial infections. In view of this, the present investigation was directed towards the design of AHL analogues employing a rational drug design approach. Novel series of ethyl bridged N-acyl Homo serine lactones has been designed and synthesized.

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