Phytochemical Screening, in-vitro Anti-Diabetic and Anti-Microbial Activities of Hydro-Alcoholic Leaf Extract of Syzygium cumini (Research Article)

Author(s): Atluri Bhavana*, Divya Sree Ch, M. Navya, Bibi Rahamatha, Shaik Zahara, T. Bhavana and K. Padmalatha

Abstract: The plant under investigation (Syzygium cumini) was a large evergreen dicotyledonous plant and belongs to the family Myrtaceae. Syzygium cumini is a medicinal plant broadly used in conventional therapeutic preparation of many pharmacological activities. The goal of our investigation was to determine whether the leaf extracts of this plant held any significant anti-diabetic, anti-bacterial and anti-fungal activities. The Phytochemical screening of hydro alcoholic extract of Syzygium cumini leaves revealed that the extract is rich in phenols, flavonoids, triterpenoids, tannins and carbohydrates. In the present study, the In-vitro anti-diabetic property of Syzygium cumini leaves extracts was analyzed by using standard methods so as to ensure the biological potency of the plant. An In vitro anti-diabetic study was done by glucose uptake by yeast cells & inhibition of α-amylase enzymes. The results of the present study concluded that the hydro alcoholic extract of Syzygium cumini exhibited between 44.44% - 98.83% in glucose uptake by yeast cells when compared to metformin & 18.36% - 93.65% in α-amylase activity while compared to acarbose in dose dependent manner. Anti-microbial activity was evaluated employing the disc diffusion and agar well method. The extract of all the fractions and Amoxycillin and Fluconazole (standard) exhibited significant anti-bacterial & anti- fungal activity. The hydro alcoholic leaf extract produced significant effects as evaluated and Zone of Inhibition (ZOI) was measured.

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