Taste Masking: Formulation and Development of Rapidly Disintegrating Tablets of Phenytoin Sodium (Research Article)

Author(s): Amanpreet Kaur Dumda*, Shrikant M. Madhekar, Swati S. Rawat, R. M. Tigote, Vaishali N Tidke.

Abstract: Aim: To Formulate and Develop of Rapidly Disintegrating Tablets of Phenytoin Sodium Taste Masking. Objective: The current work was focused to Formulate develop and evaluation of Rapidly Disintegrating Tablets of Phenytoin Sodium as taste masking. Methods: The Rapidly Disintegrating Tablets of Phenytoin Sodium were prepared by dry granulation method and direct compression method. Pre formulation studies have been performed for the Active Pharmaceutical Ingredient. Results: Drug excipient compatibility studies have been performed and the tablets have been prepared in seven different formulations with the change in the ratios of excipients. These tablets are evaluated for various parameters including the release of drug by using dissolution studies. Conclusion: Hence the study resulted in the Formulation and Development of Rapidly Disintegrating Tablets of Phenytoin Sodium comparable to the innovator product for Phenytoin Sodium which is stable.

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