Volume 11, Issue 3, July 2021
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Effect Of Vasicinone Against DNMT1 to Treat Cancer: An In-Silico Approach (Research Article)
Author(s): Niketa Singh, Km. Radha, Anisha bhatti, Fanish Kumar pandey, Noopur Khare and Abhimanyu Kumar Jha
Abstract: Cancer is a group of diseases involving irregular cell division in the human body. Cancer is the name given to a collection of related diseases. Tumors are a group of abnormal cells that form lumps or growths. According to World Health Organization (WHO) in 2019, cancer has the third rank in a further 23 century and cause of death before the age of 70 years. There were an estimated 19.3 million new cases and 10 million cancer deaths worldwide in 2020. DNMTs (DNA (cytosine-5)-methyltransferase) are overexpressed in various types of cancer. High expression of DNMT1 (DNA (cytosine-5)-methyltransferase 1) has been observed in a variety of tumors and is a characteristic change of tumor cells. DNA methylation patterns are generated during development and DNMT1 is an important methyltransferase that maintains methylation during cell proliferation. Molecular docking has a vital role in drug discovery. The molecular docking technique is used for observing the interaction between ligands and a target protein-making drug. The PDB was recognized in the year 1971 for all protein data collected in a particular platform, which is the universal archive of structural data of biological macromolecules, established by Brookhaven National Laboratories. PubChem is an open platform for chemical structures and their biological results. It was launched in September 2004 as part of a research program under the NIH Molecular Libraries.
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How To Cite this Article:
Niketa Singh, Km. Radha, Anisha bhatti, Fanish Kumar pandey, Noopur Khare and Abhimanyu Kumar Jha. Effect Of Vasicinone Against DNMT1 to Treat Cancer: An In-Silico Approach (Research Article). 2021; 11(3): 44-49.