Antibacterial Potential of Ocimum sanctum and Bryophyllum pinnatum Against Wound Pathogens (Research Article)

Author(s): *Pranita Gulhane and Nishi Selote

Abstract: Microorganisms are believed to play a significant role in impaired healing of chronic wounds which affect millions of people around the world. This problem is increased by emergence of multidrug resistant micro-organisms, especially Staphylococcus aureus and Pseudomonas aeruginosa present in hospital and community acquired infections. Medicinal plants are rich in phytochemical contents and having antimicrobial properties. Aim: Thus, aim of the present work was to investigate the antibacterial activity of Ocimum sanctum and Bryophyllum pinnatum extract against wound pathogens Staphylococcus aureus and Pseudomonas aeruginosa. Methods: Antibiotic resistance profile of the wound pathogens as well as antimicrobial activity and phytochemical analysis of both the extracts was carried out. Results: Antibiotic resistance profile of wound pathogens showed that 80% of S. aureus were resistant to oxacillin while all P. aeruginosa (100%) were found to be resistant to Trimethoprim. Antimicrobial activity of both the extracts showed that out of five S. aureus 80% were found to be sensitive to Ocimum sanctum as well as Bryophyllum pinnatum extract. On the other hand only 40% P. aeruginosa were sensitive to both the extracts. Conclusion: Both the extracts were found to be synergistically active in combination with antibiotics against the wound pathogens. Phytochemical analysis showed that in Ocimum sanctum extract Alkaloids, Glycosides and Flavonoids were present. In Bryophyllum pinnatum extract Alkaloids, Flavonoids and Saponins were present.

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