Volume 10, Issue 4, October 2020

Serum IL8 and Total Sialic Acid as prognostic marker in Patients of Alcoholic Liver Disease with cognitive dysfunction (Research Article)

Author(s): Bharati Vivek Nalgirkar*, Sneha Wadalkar and Baidarbi Chakrovorty
Abstract: Alcoholic liver disease is one of the deadliest consequence of excessive alcohol consumption and also leads to cognitive dysfunction. Serum IL-8 levels mediates neutrophilic infiltration, a pivotal process in the pathogenesis of ALD. The synthesis and the catabolism of Sialic acid takes place in the liver thus the status of liver function can influence the serum levels of TSA. OBJECTIVE The role of IL8 and TSA as a marker of liver disease and its association with cognitive changes in alcoholic liver disease. MATERIALS AND METHOD: A total of 68 cases and 50 age matched healthy controls were recruited. These patients were further categorized into 3 groups; Fatty liver, Alcoholic Hepatitis and Alcoholic Cirrhosis. Global cognitive functions were assessed periodically with Mini Mental State Examination (MMSE). Serum levels of IL-8 were determined by ELISA provided by Diaclone. Serum TSA levels were determined by Biovision’s Sialic acid assay kit. RESULT: The serum TSA levels (34.74±11.25 nmol/μl) were significantly higher in the alcoholic liver disease than in the healthy controls (2.21±1.01 nmol/μl). The serum IL8 levels (216.4± 31.4 pg/ml) were significantly higher in the alcoholic liver disease than in the healthy controls (20.±6.0 pg/ml). CONCLUSION Serum IL-8 can be used as a marker to determine stages of alcoholic liver disease and correlates with cognitive dysfunction and also shows association with poor long term prognosis. Serum TSA can be used as a marker of alcoholic liver disease and may correlate with cognitive dysfunction among ALD patients.
PAGES: 101-105  |  27 VIEWS  37 DOWNLOADS

How To Cite this Article:

Bharati Vivek Nalgirkar*, Sneha Wadalkar and Baidarbi Chakrovorty. Serum IL8 and Total Sialic Acid as prognostic marker in Patients of Alcoholic Liver Disease with cognitive dysfunction (Research Article). 2020; 10(4): 101-105.