Enhancement of Hypoglycemic Activity of Sitagliptin In Presence of Naringenin: An Herb-Drug Interaction Study in Diabetic Rats

Author(s): Pavani Uppu and Narsimha Reddy Yellu*

Abstract: Sitagliptin (SG) is a DPP-4 inhibitor class of oral anti-diabetic drug and commonly used by most of the diabetic patients. SG was mainly metabolized by CYP enzymes. The present study was conducted to know the changes in different pharmacokinetic (pk) and pharmacodynamic (pd) parameters of drug in presence of naringenin. Streptozocin was used for induction of diabetes in rats. The rats were divided in different groups and administered with suitable doses of sitagliptin and naringenin. In normal and diabetic rats pk parameters like Cmax, AUC, MRT, t½ were slightly increased, whereas volume of distribution, clearance was decreased due to the inhibition of CYP3A4 enzyme. The Combination of sitagliptin with naringenin improves the hypoglycemic activity and serum insulin levels in diabetic rats. Finally, this herb-drug combination led to the changes in different pk/pd and should be used cautiously.

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