Volume 9, Issue 1, January 2019

Antioxidant, Antimicrobial and Anticancer Properties of Phyto-Synthesized Silver Nanoparticles Using Aqueous Tuber Extract of Ceropegia spiralis Wt.

Author(s): Khaja peer Mulla, Suresh Pullani and *Yasodamma Nimmanapalli
Abstract: Biosynthesis of silver nanoparticles is under exploration due to wide biomedical applications and research interest in present advancement of nanotechnology. Ceropegia spiralis aqueous tuber extract is mixed with AgNO3, for the formation of Silver nanoparticles initially confirmed by visual observation of color change and further confirmed by using UV–Vis spectroscopy. The nanoparticles were characterized by TEM equipped with EDAX and DLS. UV–Vis result shows that maximum Surface Plasmon Resonance (SPR) band for synthesized nanoparticles at 449 nm. Transmission electron microscope result reveals spherical in shape with 10.41-23.72nm and the weight percentage of AgNPs in the sample were measured with EDAX found 72.17%. Dynamic Light Scattering data gives the size of Nanoparticles in the liquid sample found 5.0 nm along with the negative value -17 mV of Zeta potential indicates the high stability of Nanoparticles. Antimicrobial studies of AgNPs showed highest Zone of Inhibition against Staphylococcus aureus (21.67mm) and Candida tropicalis (18mm) among bacterial and fungal strains. Anticancer activity of AgNPs exhibited potential anticancer activity towards HeLa (Human Cervix Adenocarcinoma) cancer cell lines, shows 74.39% cell death with cell viability 25.61%. Overall, C. spiralis is efficient in the synthesis of nanoparticles paves a way for better antimicrobial and anticancer therapeutic drug potentials to be design by pharmaceuticals.
PAGES: 1449-1464  |  17 VIEWS  32 DOWNLOADS

How To Cite this Article:

Khaja peer Mulla, Suresh Pullani and *Yasodamma Nimmanapalli. Antioxidant, Antimicrobial and Anticancer Properties of Phyto-Synthesized Silver Nanoparticles Using Aqueous Tuber Extract of Ceropegia spiralis Wt.. 2019; 9(1): 1449-1464.