A Prospective Study on Side Effect Profile in Helicobacter Pylori Positive Patients Taking Standard Triple Therapy (Research Article)

Author(s): Limi Joseph Gomez, Arathi S Nair, Aleena Francis, Bushra Abdul Rahim, Soumya R V* and Prasobh G R

Abstract: Helicobacter pylori eradication fails in 10% of patients particularly due to occurrence of drug resistance and side effects. AIM: The objective of the research is to monitor the side effect and on tolerability of standard triple therapy to eradicate H. pylori. METHODOLOGY: A prospective observational study was carried out in the gastroenterology department for which Rapid Urease test was carried out in patients with abdominal symptom as chief complaint and 90 H.pylori positive patients were recruited for this study. The side effects were assessed using de Bore et al. questionnaire, which was provided during first and second week. In order to evaluate the impact of side effects on treatment compliance, tolerability was assessed using a 5-point scale. RESULT AND DISCUSSION: The result was analyzed using paired T test. On analyzing the tolerability, no discomfort was observed in 32 patients (36.4%) during the first week which was increased to 38 (43.3%) at the second week. Slight discomfort has been reported in about 52.3% (46 patients) and 50% (44patients) in the first and second week. Moderate discomforts were seen in 11.3% (10patients) and 6.81% (6 patients) after completion. Among all these categories bitter taste was the most common side effect. The most severe side effect which may result in discontinuation of therapy was diarrhea, whose incidence was reduced by the addition of probiotics thrice daily. CONCLUSION: Thus, it was concluded as early identification of side effect can reduce the incidence of drug discontinuation and decrease drug resistance.

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