Lipid Based Drug Delivery Systems

Author(s): K. Anie Vijetha1 and M. Sunitha Reddy*

Abstract: The formulation of lipid-based nanomedicines against various diseases has been hypothesized to improve drug localization into the in-target site and to increase the efficacy of conventional drugs, while minimizing their systemic adverse effects. Most of the treatments lack specificity, the treatment affects both target cells and their normal counterparts, many potent agents are highly toxic, and a number of chemotherapeutics are highly hydrophobic, which limits their utility in various therapies. As a result of these deficiencies, many current treatments lead to side effects, noncompliance, and patient inconvenience due to difficulties in administration. The improvement of bioavailability of drugs with such properties presents one of the greatest challenges in drug formulations. Oral lipid-based formulations are attracting considerable attention due to their capacity to increase the solubility, facilitating gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water soluble, lipophilic drug and thus increasing the bioavailability. The present review outlines the recent findings on self-emulsifying drug delivery system (SEDDS), selfmicro/nanoemulsifying drug delivery system (SMEDDS/SNEDDS) and evaluation of these formulations published over the past decade. The application of lipid-based formulations as a promising system for the oral delivery of many therapeutic agents. This review is about self -emulsifying lipid-based systems.

PAGES: 1432-1439  |  33 VIEWS  50 DOWNLOADS