A Review on Ongoing Research for Potential COVID-19 Vaccine (Review Article)

Author(s): Premjit S. Nannaware*, S. D. Mankar, Akash K. Shalke, Rajendra R. Satle and Shubham B. Mhaske

Abstract: Novel corona virus is a communicable disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first recognizing in December 2019 in Wuhan, China, and has since expanded globally, resulting in an ongoing epidemic. As of 11 May 2020, more than 4.16 million cases have been arrive across 187 countries and territories, resulting in more than 285,000 deaths. More than 1.45 million people have recovered. common symptoms include fever cough, fatigue, loss of appetite, sputum production, shortness of breath, and muscle and joint pains. While sever cases show acute respiratory distress syndrome (ARDS), multi-organ failure, septic shock, and blood clots. The standard diagnosis method is by real-time reverse transcription polymerase chain reaction (rRT-PCR) from a nasopharyngeal swab. Nowadays, the outbreak is still spreading and there is no effectual means to prevent the infection. Several organizations and institutions began work on produce vaccines for 2019 n-CoV based on the published genome. Vaccines are showed to be the most effective and economical means to prevent and control infectious diseases. Several countries, companies, and institutions declare their programs and advancement on vaccine development in opposition to the virus. While most of the vaccines are undergoing design and preparation, there are some that have entered efficacy assessment in animals and initial clinical trials. This review largely focused on the advancement and our prospects on field of vaccine development in opposition to SARS-CoV-2.

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