Cognition Enhancing and Anti-Psychotic Effect of Hydro-Alcoholic Leaves Extract of Cissampelos pareira L. (Research Article)

Author(s): Mohammad Asif, Jayesh Dwivedi, Sandeep Yadav and Prashant Desai

Abstract: Aim: The present study was performed to explore effects of leaves hydro-alcoholic extract of Cissampelos pareira L as cognitive enhancer and as antipsychotic. Methods: The leaves powder of C. pareira was extracted using hydro alcoholic solvents. Acute oral toxicity study was performed for obtained crude extract as per OECD guideline 423. Based on which three doses were selected for evaluation of cognitive enhancing using morris water maze model and anti-psychotic activity using cook’s pole climbing test. The data of the study was analysed using Graph pad prism version 3 software. Results: Acute oral toxicity study of hydro alcoholic leaves extract of C. pareira revealed that the extract displayed no sign of toxicity in mice up to dose 2000 mg/kg, based on which three doses viz 100, 200 and 400 mg/kg of C. pareira hydro alcoholic extract (CPHE) was selected. In Morris water maze model, mice of group CPHE 100, 200 and 400 mg/kg displayed cognitive enhancing activity in dose dependant manner. While, in cook’s pole climbing test, mice of group CPHE 400 mg/kg displayed anti-psychotic effect, whereas CPHE 100 and 200 mg/kg did not display anti-psychotic effect. Conclusion: Based on the results of the study, it can be concluded that treatment with hydro alcoholic extract of leaves of C. pareira justifies its traditional uses as memory enhancer and anti-psychotic. However, further detailed study is required to warrant its use in condition of AD associated with psychosis.

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