Formulation and Evaluation of Stomach Specific in-situ Gel of Urapidil Hydrochloride

Author(s): Nagaraj B*

Abstract: The present work deals with the stomach specific floating oral in-situ gel of urapidil hydrochloride by using sodium alginate as a gelling polymer and HPMC K15M as a release retardant polymer. Urapidil hydrochloride stomach specific in-situ gels were prepared by ionic gelation method using different concentrations of sodium alginate and matrix forming polymers. CaCO3 was used as CO2 gas as well as Ca++ generating agent for ionic gelation and floating. Formulation (F9) was considered to be the optimized formulation based on sustained drug release up to 10 hours and having higher viscosity, swelling index and drug content when compared to other developed formulations. Mechanism of drug release studies of optimized formulation showed zero order following non-fickian type drug release. Floating oral in-situ gelling system of urapidil hydrochloride was formulated using sodium alginate as a gelling Polymer, which sustained the drug release of 98.86% for 12 h with controlled release kinetics, while the floating lag time was 45seconds.

PAGES: 1431-1439  |  29 VIEWS  38 DOWNLOADS