Evaluation of Immunomodulatory Activity on Plant Extract (Research Article)

Author(s): Shireesha Jannapureddy*

Abstract: To study the immunomodulatory activity of methanolic extracts of ripens and dried fruits of phyllanthus acidus and pedalium murex on albino wistar rats and mice. The methanolic extracts of phyllanthus acidus and pedalium murex was administered orally at the dosage levels of 50mg/kg/day,100mg/kg/day and 200mg/kg/day body wt.in rats and mice. The assessment of immunomodulatory activity on specific & nonspecific immunity were studied by heamagglutination antibody (HA) titer, delayed type hypersensitivity (DTH) and carbon clearance test. The Levamisole is used as standard immunomodulating agents. Oral administration of phyllanthus acidus and pedalium murex showed a significant increase in the production of circulating antibody titer in response to sheep red blood cells (SRBCs).A significant (P < 0.01) increase in both HA titer was observed when compared to control groups. They showed significantly (P < 0.01) potentiated the DTH reaction by facilitating the foot pad thickness response to SRBCs in sensitized rats. Also, they evoked a significant (P < 0.01) increase on the phagocytic activity.

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