Anxiolytic effects and Chemical profile of leaf oil of Skimmia anquetilia (Research Article)

Author(s): Vijender Kumar*, Rakesh Chawla, Sandeep K. Goyal, Z A Bhat

Abstract: Skimmia anquetilia (Rutaceae) leaf has been used in traditional medicines for various disorders, no attempt has been carried out to scientifically investigate the plant for its traditional claims. The current investigation was carried out to isolate oil from leaves of Skimmia anquetilia (Rutaceae), chemically characterized and investigated for its anxiolytic potential. The anxiolytic properties were evaluated by elevated plus maze and light/dark arena tests in rats. GC/MS analysis of Skimmia anquetilia oil (SAO) indicated the presence of major phytoconstituents like vetiverol (37.315%), pregeijerene (15.136%), linalool (10.085%), β-fenchyl-alcohol (7.715%), geranyl acetate (5.588%), terpinyl acetate (3.300%), α –pinene (3.726%), β-phallendrene (2.624%), neryl acetate (2.433%), (Z.E) - α-farnesene (2.012%), geraniol (1.463%) and limonene (1.362%). The anxiolytic studies of S. anquetilia oil was conducted at dose level of 25 and 50 mg/kg, body weight. The SAO shown significantly dose dependent increased number of entries and time spent in open arms on the elevated plus maze test while as in the light/dark arena test, SAO showed an increase in number of crossings and time spent in light arena. The current studies are indicative that SAO has validated its traditional claim as anxiolytic potential.

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