Preparation and Evaluation of Mebendazole Tablets by Using Liquisolid Technique to Enhance Its Dissolution Rate (Research Article)

Author(s): Jadhav Pooja N.*, Buchade Rahul S. and Shaikh Amir A.

Abstract: Liquisolid technology has been applied to prepare water-insoluble drugs into rapid-release solid dosage forms. In this case, even though the drug is in a solid dosage form, it is held within the powder substrate in solution or, in a solubilized, almost molecularly dispersed state, which contributes to the enhanced drug dissolution properties. With Liquisolid technique liquid formulations such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into acceptably flowing and compressible powders by simple physical blending with selected excipients named the carrier and the coating material. The liquisolid approach has been successfully applied in release enhancement of low dose poorly soluble drugs. Liquisolid system is characterized by flow behavior, saturation solubility, drug content, Fourier transform infra-red spectroscopy, in-vitro release and in vivo evaluation. By using this technique, solubility and dissolution rate can be improved for the water soluble drugs.

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