Impaired Antioxidant Enzyme Activities in Kidney and Liver Tissues of Hypertension Induced and Vanadium Treated Rats

Author(s): V. Visali, P. Venkata Viswa Prasad, C. Mamatha, S. Payani and M. Bhaskar*

Abstract: Hypertension is a complex disorder that affects various organs of the body. The vital target of the present research was to study the effect of hypertension induction and vanadium treatment On antioxidant status in various tissues of the rat. In the present work, four domains of rats were taken i.e., Control domain, fructose-induced hypertension domain, vanadium treated domain, hypertension-induced + vanadium treated domain. The actions of antioxidant enzymes SOD (Superoxide dismutase), Lipid peroxidation, catalase, Glutathione peroxidase (GPX) were estimated in the kidney and liver of all the four domain rats. The result reveals that hypertension induction significantly reduced the levels of SOD, lipid peroxidation and in Contrast the catalase, glutathione peroxidase levels in both kidney and liver were significantly increased whereas the treatment with sodium met vanadate effectively reestablished the alterations in the antioxidant enzymes in both kidney and liver tissues of the rat.

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