Volume 9, Issue 4, October 2019

Formulation, Characterization and Comparison of Cefaclor and Cefdinir Microspheres

Author(s): Y. Manjula Devi* and G. Sailaja
Abstract: The purpose of this research work is to increase and compare the residence time of drugs Cefaclor and Cefdinir by formulating as floating microspheres and to study the effect of formulation variables on microspheres characteristics. Microspheres are prepared by solvent evaporation method. For each drug nine different formulations are prepared by changing drug to polymer ratio, volume of internal phase, volume of external phase and stirring time. The prepared microspheres are characterized for drug - polymer compatibility by IR, percentage yield, particle size analysis, drug entrapment efficiency, and surface morphology by SEM, bulk density, percentage buoyancy, in-vitro release and release kinetic studies. Results of these evaluations showed that particle size in the range of 100.8±1.6 μm to 106.2±1.3μm, and102.1±1.3 to 108.6±1.7 entrapment efficiency is found to be 75.72±1.94 to 92.02±1.07% and 75.69±1.91 to 89.45±1.63% and drug content is found to be in the range 95.55±1.4 to 99.92±2.67 and 96.89±2.1 to 99.11 ± 2.1 respectively. Fourier-Transform Infra-Red (FT-IR) studies ensured that no drug - polymer interaction in the formulated microspheres is found. The surface topography revealed a spherical surface for all the formulations and a round cavity enclosed by an outer shell composed of the drug and polymer. In- vitro release profile of microspheres for F14 and F23 formulations are found to be 98.45±0.47 and 99.87±0.36 at the end of 12hrs. In release kinetic studies, the F14 and F23 formulations followed zero order and first order drug release with non-Fickian diffusion mechanism.
PAGES: 104-114  |  32 VIEWS  35 DOWNLOADS

How To Cite this Article:

Y. Manjula Devi* and G. Sailaja. Formulation, Characterization and Comparison of Cefaclor and Cefdinir Microspheres. 2019; 9(4): 104-114.