Formulation and Evaluation of Oral Fast Disintegrating Tablets of Delafloxacin

Author(s): Pinumalla Kavya Sree*, Srinivas Martha, JVC Sharma and Beda Durga Prasad

Abstract: The present study is to formulate and evaluate oral fast disintegrating tablets of Delafloxacin by direct compression method. In the present study an attempt has been made to prepare oral fast Disintegrating tablets of Delafloxacin using Crospovidone and cross linked PVP to increase the rate of drug release from dosage form to increase the dissolution rate. Direct Compression method was used to formulate the tablets. All the formulations were showed the acceptable flow properties and the pre compression parameters like Bulk density, Tapped density and Carr’s compressibility index and Hausner ratio. The post compression parameters like Weight variation, friability, hardness, disintegration, wetting time, water absorption ration and In vitro dissolution profile values were found to be within specified limits. From the data obtained, it is observed from the formulation F3, shows Disintegration time in 30 seconds and the Percentage drug release is of 99% at the end of 14 min which satisfied all the tablet evaluation parameters for oral fast disintegrating tablet.

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