Novel Approach On Solubility Enhancement: Solid Dispersion a Brief Overview

Author(s): Shalu Verma* and Mohini Rawat

Abstract: Aim- ‘Solid dispersion’ means a mass of solid products which consist of at least two different components, generally a hydrophobic drug and hydrophilic matrix. Solid dispersion is used in pharmaceutical industry for increasing the absorption, dissolution rate and therapeutic efficacy of the drug. Hydrophilic polymers are the mainly used carrier for the preparation of solid dispersion. Melting method & Solvent evaporation method are two widely used approaches in preparing solid dispersion and solid solutions. Method- Solid dispersion are prepared by different methods like solvent evaporation method, hot melting method, fusion method etc. Solvent evaporation method is the widely used method in pharmaceutical application. In solid dipersion both drug and its carrier is agitated in a same common solvent, under vacuum, which is evaporated to produce a clear, solvent free film is remain left. Further the film is dried to constant weight. Result- Solid dispersion is the most used method to improve the solubility of poorly soluble drug in water. Solid dispersion helps to improve the bioequivalence and bioavailability. The increasing dissolvable property of solid dispersion is mainly because of amorphous form of drug is related with a higher energy state as contrast to its crystalline structure. Conclusion- Solid dispersion is a widely used method for distribute Lipid soluble drug by oral route. It is the most efficacious method to attain the aim of enhancement of dissolution of poorly water soluble drugs. Solid dispersion technique is used both in laboratory scale and at industrial scale also.

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