Formulation and Evaluation of Solid Lipid Nanoparticles of Alendronate Sodium using Different Lipids

Author(s): Rohit Suman*, Jayanthi, Mitali k. Sah, Nivedita and Jit Narayan Sah

Abstract: Solid lipid nanoparticles are the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research. The purpose of this research was to develop novel particulate carriers such as Solid Lipid Nanoparticles (SLN) of Alendronate Sodium as an anti-osteoporotic agent which was prepared by hot homogenization method to sustained release of drug and to improve bioavailability and to study its effects. The factorial design was used to design the formulation of Solid Lipid Nanoparticles of Alendronate Sodium. Glyceryl Monostearate (GMS), Compritol, Dynasan as lipid, Poloxamer as surfactant and Stabilizer are used for Solid Lipid Nanoparticle preparation. The entrapment efficiency and drug content indicated that, as the concentration of drug to polymer ratio increases the entrapment efficiency and drug content also increases. Based on entrapment efficiency and in-vitro behavior, formulation code F7 was considered as the optimized formula. The particle size was found to be 202 nm. The compatibility study, DSC is performed on optimized formulation. In-vitro study showed the controlled release of SLN formulation on Pure Alendronate Sodium drug over a period of 36 hrs. At the end of accelerated stability studies for the selected formulation F7 showed almost same drug content, entrapment efficiency, in vitro drug release and no changes observed when compared to the initial product.

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