Design, Preparation and Characterization of Minoxidil Transdermal Patches

Author(s): V. Lokeswara Babu*, Mohd Salman Qurshed Aiam , Y. Sirisha and P Udaya Chandrika

Abstract: Minoxidil transdermal patches were prepared to sustain the release and improve bioavailability of drug and patient compliance. Different formulations were prepared using various polymers by solvent casting method. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % moisture content, % moisture uptake, % drug content and in vitro drug release. Formulation F2 was selected as optimized formulation which contains HPMC and ethyl cellulose with in vitro drug release of 96.89±0.59% in 12 hr. The release profile of Minoxidil followed Higuchi and peppa’s kinetics in different formulation. However, the release profile of the optimized formulation F2 indicated that the release of the drug from the patches was governed by a diffusion mechanism.

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