Formulation and Evaluation of Atorvastatin Matrix Tablets by Using Wet Granulation Method

Author(s): Madiha Nishath*, Shaik Shabbeer, P.Poli Reddy, B. Bharathi

Abstract: The objective of the study was to formulate and evaluate the matrix tablets of various concentrations of natural and synthetic hydrophilic polymers on in-vitro release rate from the prepared Atorvastatin matrix tablets. The Atorvastatin matrix tablets were developed by wet granulation method using natural polymers and synthetic polymers at various concentrations and its effect were compared. The formulations were evaluated for hardness, friability, weight variation, disintegration, and in vitro release study. Set of trials were formulated for which Atorvastatin evaluated parameters (bulk density, tapped density, compressibility index, hausner’s ratio, weight, thickness, hardness) were found to within the specifications. Dissolution study was performed in USP type II apparatus at 100 RPM in 0.1 HCL for 2 hours followed by pH 1.2 and pH 6. 8 phosphate buffers. From the results of the invitro study it appears that the release of the Atorvastatin was significantly influenced by the characteristics of the polymer used.

PAGES: 1300-1309  |  236 VIEWS  293 DOWNLOADS