Formulation and Optimization of Floating Microspheres of Ivabradine Hydrochloride by 32 Factorial Design Approach

Author(s): Sagar N Firke*, Pritam R Siraskar, Dhiraj H Nagore and Nitin B Ghiware

Abstract: The Present study is an attempt to design and formulate floating microsphere of Ivabradine Hydrochloride to achieve its release in a controlled manner and to avoid its repetitive administration thereby, to improve the bioavailability. Ivabradine floating microspheres were prepared by multiple emulsion solvent evaporation technique (w/o/w) using Ethyl Cellulose as polymer, Dichloro Methane as solvent for polymer and tween 80 was used as emulsifying agent. The Formulation was optimized by 32 factorial design, by means of polymer concentration and stirring speed as an independent variables and drug loading, particle size and % drug release was selected as a response along with other micromeritic properties such as particle size, bulk density, tapped density and flow ability. Formulation prepared by using 400 mg of Ethyl cellulose gives the highest yield of 89.10±10 %, 91.5±0.10 % of drug loading, 162.55 μm of average particle size,78.20±0.27 percent of drug release in 8 hours and 92.10±0.26 of Buoyancy. The optimized formulation was found suitable to be dispensed as a single unit dosage form in the form capsules.

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