Vitamin E Hydroquinone is an Endogenous Regulator of Ferroptosis Via Redox Control of 15-Lipoxygenase

Author(s): Nagarathna PKM, Babiker Bashir, Godfrey, Harsha Vardhini N and K. Ramesh

Abstract: Ferro ptosis is a form of programmed cell death associated with inflammation, neuron degeneration and ischemia. Vitamin E (alpha-Tocopherol) has been reported to prevent Ferro ptosis but the mechanism by which this occurs is controversial and inhibits 15-lipoxygenase via reduction of the enzyme’s non-heme iron from its active Fe3+ state to an inactive Fe2+ state1.Composed of vitamin E, four Tocopherols and four tocotrienols, works as anti-oxidant fat to break fat chain that prevent oxidation of fat .The liver is the focal point of regulating the absorption of lipoprotein lipase synthesis by reverse, which is the site of detoxification Alexei by cytochrome p450 enzymes systems in the oxidation (Phase 1), proposal (phase 2), and transporters (Phase 3)).The impact of a-Tocopherol in the prevention of chronic diseases believed to be associated with oxidative stress has often been studied, and beneficial effects have been demonstrated Due to the potent antioxidant properties of Tocopherols.

PAGES: 1008-1013  |  132 VIEWS  279 DOWNLOADS