Formulation and Evaluation of Vitamin D3 (Cholecalciferol) Self-Nanoemulsifying Drug Delivery Systems for Enhancing Solubility

Author(s): Syed Umar Farooq*, D Sudheer Kumar and Abdul Azeez Shahid

Abstract: A self-nanoemulsifying drug-delivery system (SNEDDS) improves the solubility and dissolution profile of poorly soluble drugs. Different formulations were prepared using different oils, surfactants and co-surfactants. A pseudo ternary phase diagram was constructed to identify the self-micro emulsification region. Further, the resultant formulations were investigated for clarity, phase separation, drug content, % transmittance, globule size, freeze-thaw, in vitro dissolution studies, particle size analysis and zeta potential. On the basis of particle size, zeta potential and dissolution profile and other studies, (D29) was found to be the best formulation of Vitamin D3SNEDDS. The particle size of the emulsion is a crucial factor in self emulsification performance because it determines the rate and extent of drug release as well as absorption. The average particle size of Vitamin D3SNEDDS for transparent micro-emulsions should be less than 100nm. The particle size of the optimized SNEDDS formulation was found to be 51.2 nm and zeta potential was found to be -12.6 mV which comply with the requirement of the zeta potential for stability. The faster dissolution from SNEDDS may be attributed to the fact that in this formulation, the drug is a solubilized form and upon exposure to dissolution medium results in small droplet that can dissolve rapidly. The % release from optimized SNEDDS formulation D29 was highest (99.72%) and faster than Vitamin D3 Capsule (63.29%) and other SNEDDS formulations indicating influence of droplet size on the rate of drug dissolution. Thus, Vitamin D3 with SNEDDS formulation may be used for the improvement of solubility and dissolution rate.

PAGES: 587-598  |  64 VIEWS  41 DOWNLOADS