DESIGN AND DEVELOPMENT OF ZIPRASIDONE LIPOSOMES FOR INTRANSAL ADMINISTRATION

Author(s): Manda Suma, Vasavi Reddy Devireddy and Srinivas Reddy Devireddy

Abstract: Ziprasidone is an atypical antipsychotic agent used for the treatment of schizophrenia. Sustained release of the ziprasidone liposome may reduce the frequency of administration. The blood brain barrier showed one of the difficult barriers for drug delivery. The barrier is limited for exchange of hydrophilic compounds, proteins between central nervous system and plasma. To overcome these limitations carrier system like liposomes, niosomes, microspheres, microparticles drug deliveries mainly used for brain targeting because these methods of preparation are easy, simple and easy to scale up. Intranasal drug delivery is one of the focused deliveries for brain targeting. Drugs which under goes first pass metabolism to avoid these and increases their bioavailability of drug nasal route is preferred. Liposomes are prepared by ethanol injection method and material used are cholesterol, lecithin. These liposomal preparations are characterized by FTIR and DSC analysis, pH, Drug content, vesicle size, PDI, zeta potential, % entrapment efficiency and percentage of drug release, release kinetics, ex-vivo nasal permeation studies. Optimized F4 ziprasidone liposomal formulation showed 67.6±1.97% Entrapment efficiency and 84.6±0.33% of drug release at 12th hour. Intranasal administration of ziprasidone liposomes significantly increased the bioavailability.

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