Synthesis of Novel Bicaultamide Related Derivatives and their Evaluation of Biological Activity

Author(s): Subrahmanyam Lanka*, Vaikuntarao Lakinani, Sagar Rao Kanaparthi, Siva Rama Rao Kakani

Abstract: A novel approach for the synthesis of novel Bicaultamide related derivatives (11-16) from (1S)-1-(oxiran-2-yl)-2-phenylethan-1-amine. The epoxide on treatment with Alkyl amines in presence of a potassium tert-butoxide followed by synthesis of Alkyl/Aryl sulphonamides on reaction with substituted sulphonyl chloride. All the synthesized compounds were screened in vitro for their antibacterial activity against two gram positive bacteria Staphylococcus aureus (MTCC – 96), Bacillus subtilis and two gram negative bacteria Escherichia coli (MTCC – 443), Pseudomonas aeruginosa (MTCC – 424) by the cup-plate agar diffusion methodat different concentrations (1 mg /mL).

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