Formulation and Evaluation of Buccoadhesive Drug Delivery System of Acebutolol Hydrochloride

Author(s): Swapnali Zore*, Bhaskar Bangar and Akshay Shingate

Abstract: The main aim of this work was to formulate and study buccoadhesive buccal tablet of acebutolol using various suitable bioadhesive polymers such as Carbopol 934, HPMC K4M. Backing layer of ethyl cellulose was used by direct compression method. The prepared tablet where characterized by bioadhesive properties in vitro dissolution studies. In the last two head decades bucoadhesive drug delivery system has taken a huge life from the research laboratories to the hands of patients this dosage forms gain attention B’coz of their non-invasive administration. Rapid onset of effect good bioavailability elimination of hepatic first pass metabolism reduce amount of administered dose and dose related side effect this are available as tablet patches films vapours and semisolids like gels and ointment such formulations must be of convenient size and geometry and should other tightly or alternatively should erode completely duration of the application. The purpose of this research was to formulate and evaluate bioadhesive buccal tablets of acebutolol using HPMC K4M as a sustained release polymer, as ethyl cellulose as an impermeable backing layer. The tablets were evaluated for weight variation, thickness, hardness, friability.

PAGES: 124-132  |  43 VIEWS  63 DOWNLOADS