Formulation and Evaluation of Celecoxib Solid Dispersion

Author(s): Lawale Harshada*, Deshmukh Madhuri, Shete Rajkumar and Solunke Rahul

Abstract: Aim: The purpose of present study is to develop stomach specific celecoxib solid dispersion using eudragit EPO as a carrier for enhancing solubility as well as rate in gastric environment. Method: Enhanced dissolution rate and solubility in gastric pH was achieved by formulating celecoxib solid dispersion by hot melt extrusion techniques. The celecoxib solid dispersion prepared by 2² factorial design. The drug and eudragit EPO in different ratios like 1:1,1:2,1:3 and 1:4 were used for formulating solid dispersion. Results: FTIR spectra of celecoxib in alone and combination showed compatibility of drug and excipient. The solid dispersion was evaluated for percentage yield, drug content and percent drug release and results found to be 97.50%,99.43% and 87.97% respectively. Stability study was performed in closed container at 30 oC +̱2 oC/65% RH+̱5% RH and 40 oC+̱2 ̊C/75% RH +̱ 5% RH. Conclusion: It was concluded that 1:1 ratio of celecoxib solid dispersion shows better in-vitro dissolution rate as compared to pure drug The increased dissolution rate of celecoxib solid dispersion in gastric pH was attributed to the effect of eudragit EPO which was clearly shown by SEM, DSC and P-XRD studies.

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