Designing and Screening of Substituted Oxadiazeno Indole Derivatives for Anti-Depressant Activity by In-Silico and Docking Studies

Author(s): K. Pavani and K. Swathi*

Abstract: Isatins and its analogues are the most variable substrates used for the synthesis of number of heterocyclic compounds. These derivatives possess different biological activities like anti-depressants1, anti-convulsant2, sedative -hypnotic3, anti –histamines5, anti-cancer6, anti-inflammatory7, antimicrobial, antioxidant9 and anti-bacterial10. So, for the past few decades these derivatives are received much attention. Because of these therapeutic uses, docking studies are performed with a new series of substituted oxadiazeno indole derivatives using target as selective serotonin reuptake transporter as protein(PDB:6DZW) In silico studies like molinspiration, Swiss ADME are also performed.Among all the compounds, substitution with chlorine, bromine and iodine shows good activity to treat depression. So, based on these docking studies and In silico results we planned to synthesize the compounds which shows good activity

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