GCMS Analysis and Zebrafish Studies Reveal Presence of Antilipidemic Phytochemicals in Methanolic Seed Extracts of Phaseolus vulgaris

Author(s): Suma Sarojini and Della Mariya Thomas

Abstract: The past few decades saw a rise in cases of metabolic syndrome (MetS) which includes visceral obesity, dyslipidaemia, hyperglycaemia, and hypertension. This has become a major focus of the World Health Organization (WHO) and is now commonly referred to as an "epidemic of obesity and diabetes" ("diabesity"). Multiple factors have contributed to MetS, the most significant being adoption of a diet characterized by excessive consumption of simple sugars and salt, saturated and trans-esterified fatty acids and a sedentary lifestyle. Though severe cases require pharmacologic interventions, borderline cases can be treated using phytochemicals. Scientists world over are in search of potential phytochemicals to reduce the damage of MetS. The current study involves a preliminary screening of methanolic seed extracts of Phaseolus vulgaris in reducing cholesterol levels, one of the factors which contributes to MetS. The extracts were analysed by GCMS and preliminary in vivo studies conducted using the model organism, zebra fish (Danio rerio).

PAGES: 796-802  |  58 VIEWS  238 DOWNLOADS