Evaluation of Paracetamol Overdose on the Wistar Rat’s Liver

Author(s): Shekhar Kumar Sinoriya* and Kusum Singh

Abstract: It has been reported that the liver gets damaged due to overdose of many drugs including paracetamol, several researchers reported a number of hepatoprotective drugs to overcome damage in liver cells. Since a large no. of population uses paracetamol it becomes necessary to evaluate the toxicity and to develop a drug to overcome it. Present study is done to evaluate toxicity of liver due to overdose of paracetamol in Wistar rats. Three doses 1500, 2500 and 3500 mg/kg/ day were given for 3 consecutive days to Wistar rats and various biochemical parameters were performed. To support the study, histopathology of liver was also done simultaneously. It was observed that the Wistar rats were totally resistant to paracetamol except slight gastric ailments. The result of this research is that, the Wistar strain of rat is not suitable for study of paracetamol induce hepatotoxicity.

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