Volume 9, Issue 1, January 2019

Impact of Cucurbita maxima Seed Extract on Hepatorenal Profile of Severely Diabetic Rats

Author(s): Devesh Kumar Kushawaha, Manjulika Yadav, Sanjukta Chatterji and Geeta Watal*
Abstract: Aims: Antidiabetic potential of Cucurbita maxima seeds extract (CMSE) has already been published by our research group. So, the present study deals with the impact of CMSE on hepatic and renal profile of diabetic rats to validate our previous findings. Methods: The long term study of four weeks with the most effective dose of 200 mg kg-1 of CMSE was carried out to assess its hepatoprotective and renal protective impact on streptozotocin (STZ) induced severely diabetic rats. The enzymes taken into consideration were aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALKP) and creatinine (CRTN) in addition to hemoglobin (Hb) and total protein (TPR). Results: The maximum fall shown by CMSE in levels of AST, ALT, ALKP, CRTN was 45.9, 47.7, 40.4, 49.5% respectively. Whereas, in case of positive control, treated with 2.5 mg kg-1 of glipizide, the maximum fall was of 35.2, 40.9, 38.7, 30.0% in case of above enzymes respectively. Moreover, CMSE showed a maximum rise of 39.6 and 59.1% in Hb and TPR levels respectively. Whereas, glipizide treated rats showed much less improvement in Hb and TPR levels with a rise of only 7.3 and 20.3% respectively. The untreated diabetic rats continued to show enhanced levels of AST, ALT, ALKP and CRTN in addition to slight percentage fall in Hb and TPR levels. Conclusion: Thus, the present study not only reveals the impact of CMSE on hepatic and renal profiles of severely diabetic rats but also validates the previous reports of hypoglycemic and antidiabetic effects of CMSE.
PAGES: 925-929  |  24 VIEWS  25 DOWNLOADS

How To Cite this Article:

Devesh Kumar Kushawaha, Manjulika Yadav, Sanjukta Chatterji and Geeta Watal*. Impact of Cucurbita maxima Seed Extract on Hepatorenal Profile of Severely Diabetic Rats. 2019; 9(1): 925-929.