Oxidative Stress Products in Diabetic and Non-Diabetic Cataract Lens - A Pilot Study

Author(s): G. Swathy, Suhas Prabhakar*, C. Umamaheswara Reddy and C. K. Dhanapal

Abstract: Purpose: The study aims to evaluate the alterations in the levels of oxidative products and enzymatic antioxidants in the lenses of diabetic and non-diabetic cataract patients. Methods: The levels of malondialdehye (MDA), conjugated diene (CD), advanced oxidation protein products (AOPP) and the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) were measured in the lenses of 30 diabetic and 30 non diabetic patients who underwent cataract surgery. Results: Our results show significantly higher MDA, CD and AOPP levels as well as decreased SOD and GPx activity in diabetic cataract when compared to nondiabetic cataract lenses. Conclusion: The study indicates an increased lipid peroxidation with correspondingly decreased antioxidant defense in diabetic cataract which suggests a vital role for oxidative stress in the pathogenesis of diabetic cataract.

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