Anti-Obesity Efficacy of Selected Plants Against Progesterone Induced Obesity

Author(s): Asra Fathima, Niveditha TS and Farhath Khanum*

Abstract: The aetiology of obesity is multifactorial and is becoming a major health concern in the current scenario. Hormone imbalance is one the reasons for the development of obesity. Progesterone is a neurosteroid female reproductive hormone. Imbalance in the production of this hormone modulates lipid metabolism leading to obesity. Numerous trials have been conducted to find and develop new anti-obesity therapy through herbal approach to minimize side effects associated with the currently available anti-obesity drugs. The present study was designed to evaluate antiobesity efficacy of 3 plants selected; Citrus limon, Nigella sativa and Cyperous rotundus against progesterone induced obesity in female BALB/C mice. Progesterone was administered subcutaneously, and plant extracts was given orally for 28 days. Food intake and body weight gain were monitored regularly and lipid profile, neurotransmitters (serotonin and dopamine) which play key role in energy homeostasis were analysed. The results suggests among the 3 plants, Citrus limon and Nigella sativa showed better reduction in the levels of circulating free fatty acids, lipid profile resulting in decrease food intake and body weight gain in female BALB/C mice in comparison with progesterone treated group followed by Cyperous rotundus at dose of 400mg/kg b w. Thus, these plants can be considered as an effective treatment in management of obesity owing to their potential anti-obesity effect.

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