AN EFFICIENT ECOFRIENDLY SYNTHESIS OF 1, 2-DIHYDROQUINAZOLINONES BY USING CLAY AS CATALYST

Author(s): Rekha Lagarkha and Kameswara Rao Chivukula

Abstract: A simple, efficient and eco-friendly method for the synthesis of quinazolinones has been developed using water as solvent. This protocol involves one pot reaction of readily available substituted isatins and 2-aminobenzamide with montmorillonite-K-10 as a green and eco-friendly catalyst. This method is carried out in shorter reaction time with operational simplicity, higher yields and selectivity. Using this method, a series of fifteen compounds were synthesized.

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