Evaluation of DNA Binding Antimicrobial and Cell Viability Activity of Furan-Based Cobalt (III) Polypyridyl Complexes

Author(s): Ch. Ravi, Ravi Kumar Vuradi, Srishailam Avudoddi

Abstract: This article describes the DNA binding properties of three new Cobalt (III) Polypyridyl complexes [Co(phen)2CMIP]3+ (1), [Co(bpy)2CMIP]3+ (2) and [Co(dmb)2CMIP]3+ (3) where CMIP=2-(2-Chloro-8-methylquinolin-3-yl)w-1H-Imidazo[4,5-f][1,10]phenanthroline, phen = 1,10-phenanthroline, bpy = 2, 2′ bipyridine and dmb = 4, 4 - dimethyl-2, 2′- bipyridine. They have been synthesized and characterized by IR, 1H &13C NMR and Mass spectra. The DNA – binding constant (Kb) of the complexes was determined to be in the order of 106 with an intercalative mode of binding. Photoactivated cleavage and antimicrobial studies of three complexes were shown better results, Cytotoxicity (MTT assay) showed growth inhibition in dose dependent manner. Among three complexes, complex 1 was more active than other two complexes.

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