Volume 9, Issue 1, January 2019

Design and Characterization of Transfersomal Patch of Aceclofenac as a Carrier for Transdermal Delivery

Author(s): Sandesha Majukar*, P M. Dandagi and B K. Kurangi
Abstract: Aim: The objective of present investigation has been focused on formulation and characterization of aceclofenac loaded transfersomal transdermal patch as an alternative delivery method for localized drug action to the targeted site. Methods: Aceclofenac was encapsulated into transferosome vesicle by thin film hydration technique using different edge activators and characterized for particle size, vesicle morphology by scanning electron microscopy, entrapment efficiency and drug release. Later, the optimized SP2 and TW3 transferosome formulations were selected for patch preparation by solvent casting method. Result: Transfersomal vesicles were found to be nanometric range [below 400 nm] with spherical structure. SP2 formulation showed maximum drug release of 86.4 % and entrapment efficiency of 76 % wherein TW3 formulation showed maximum drug release of 92.3 % and entrapment efficiency of 64 %. Vesicles formed with tween 80 are smaller than that with span 80. Based on the in vitro permeation studies, aceclofenac loaded transfersomal patch was found to have greater drug permeation than a plain patch of aceclofenac. The results obtained revealed that aceclofenac in all the formulations was successfully entrapped with good uniformity and followed Higuchi’s drug release kinetic model with non-fickian mechanism. Conclusion: This research work suggested that aceclofenac loaded transfersomal transdermal patch can be a novel alternative approach to oral therapy in the treatment of arthritis.
PAGES: 1138-1147  |  25 VIEWS  32 DOWNLOADS

How To Cite this Article:

Sandesha Majukar*, P M. Dandagi and B K. Kurangi. Design and Characterization of Transfersomal Patch of Aceclofenac as a Carrier for Transdermal Delivery. 2019; 9(1): 1138-1147.