IN VITRO ANTICANCER ACTIVITY OF ETHYL ACETATE EXTRACT OF PREMNA LATIFOLIA AGAINST MCF-7 CELL LINE

Author(s): R. Krishnamoorthi* and K. Elumalai

Abstract: The aim of the present study is to evaluate the effect of in vitro anticancer activity of the ethanolic extract of Premna latifolia against mCF-7 human breast cancer cell line using MTT assay showed a percentage of cell viability of 49% at 25μg/ml which decrease with increase in concentration of extract. Anticancer activity of ethyl acete extract of premna latifolia on Mcf-7 human cancer cell line showed potent cytotoxic activity. The inhibition percentage with regard to cytotoxicity was found to be 52% at 75μg/ml which was comparable to the control Cyclophosphamide that showed a cytotoxicity of 55%. Therefore, the minimum effective concentration of ethyl acetate extract of Premna latifolia was toxic to Mcf-7 cells was recorded at a concentration of 25μg/ml of the ethyl acetate extract of premna latifolia.

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