Volume 9, Issue 1, January 2019

Anti-Hepatotoxic Effect and Phytochemical Analysis of Berberis Aristata Bark Against Carbon Tetrachloride-Induced Hepatic Damage in Rats

Author(s): Sachin S. Bhusari* and Pravin S. Wakte
Abstract: Aim: To evaluate anti-hepatotoxic activity and phytochemical analysis of Berberis aristata bark against carbon tetrachloride induced hepatic damage in rats. Method: The petroleum ether, ethyl acetate, chloroform, n-butanol, and ethanol extracts of Berberis aristata bark were evaluated for its anti-hepatotoxic activity using carbon tetrachloride induced hepatic damage in rats. Hepatoprotective activity was evaluated by measuring reduction in levels of serum marker enzymes namely serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase and alkaline phosphatase after carbon tetrachloride treatment. Result: Carbon tetrachloride intoxication has resulted in increased serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase and alkaline phosphatase levels. Among five different extracts treated groups, petroleum ether extract treated group has shown significant reduction in levels of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase and alkaline phosphatase. Conclusion: The hepatoprotective activity of petroleum ether extract of the Berberis aristata bark may be due to presence of berberine or other alkaloids in combination.
PAGES: 616-621  |  22 VIEWS  40 DOWNLOADS

How To Cite this Article:

Sachin S. Bhusari* and Pravin S. Wakte. Anti-Hepatotoxic Effect and Phytochemical Analysis of Berberis Aristata Bark Against Carbon Tetrachloride-Induced Hepatic Damage in Rats. 2019; 9(1): 616-621.