Volume 9, Issue 1, January 2019

Evaluation of Anti-Catatonic Effect of Stem Extracts of Securinega leucopyrus on Haloperidol Induced Catatonia in Rats

Author(s): G. N. S. S. Chandra Sekhar*, J. Gopi Chand, S. Amreen Sultana, K. Lakshmi, D. Eswar Tony, A. Narendra Babu and Rama Rao Nadendla
Abstract: The present study was undertaken to evaluate the anti-catatonic activity of methanolic and aqueous extracts of Securinega leucopyrus on haloperidol induced catatonia in rats. The study comprises of five groups (Negative control, Positive control, Standard, Aqueous stem extract, Methanolic stem extract), each containing five animals. Animals in groups I, III, IV & V were administered with haloperidol to produce extra pyramidal side effects. The severity of the catatonia was evaluated by block method and is scored. The methanolic (SLME) and aqueous (SLAE) extracts have shown significant anti-catatonic effect at a dose of 100mg/kg, p.o., showing an overall p value<0.05 when compared to other groups. SLME has more ability to reduce the extra pyramidal effects than SLAE. The results suggest that both the extracts can be used for anti-catatonic activity.
PAGES: 337-341  |  28 VIEWS  37 DOWNLOADS

How To Cite this Article:

G. N. S. S. Chandra Sekhar*, J. Gopi Chand, S. Amreen Sultana, K. Lakshmi, D. Eswar Tony, A. Narendra Babu and Rama Rao Nadendla. Evaluation of Anti-Catatonic Effect of Stem Extracts of Securinega leucopyrus on Haloperidol Induced Catatonia in Rats. 2019; 9(1): 337-341.