IN VITRO CYTOTOXICITY AND ANTIOXIDANT STUDY OF DIFFERENT EXTRACTS OF BOERHAVIA DIFFUSA LINN IN CARDIAC H9c2 CELL LINE

Author(s): U. Kanagavalli*, A. Mohamed Sadiq and M.D. Lakshmipriya

Abstract: Boerhavia diffusa linn (BD) is known as a health food but its beneficial effects in protecting cardiomyocytes remain elusive. The aim of the present study was to evaluate the in vitro cytotoxic activity of methanolic, hexane and ethylacetate extract of a whole part of Boerhavia diffusa linn on H9c2 cardiomyocytes cell lines. Antioxidant activity of the plant extracts were characterized by using SOD, catalase and glutathione peroxidase method. The cytotoxic activity of the extracts of Boerhavia diffusa linn on H9c2 cells was investigated in vitro through MTT assay. The results showed Antioxidant activity using SOD, catalase and glutathione peroxidase were found to be increased in a concentration dependent manner and decreased cell viability and cell growth inhibition in a dose dependent manner. The findings from this study indicated that methanolic extract of Boerhavia diffusa linn possessed vast potential as a medicinal drug especially in cardioprotective treatment.

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